Dr Lederman, Dr Hosack and colleagues from the University of Arizona College of Medicine Phoenix discuss the potential for Vancomycin Powder to prevent infection in shoulder replacement.

Title: In vitro susceptibility of Propionibacterium acnes to simulated intrawound vancomycin concentrations

Luke Hosack MD MS, Derek Overstreet PhD, Evan S Lederman, MD

Background

There is convincing evidence supporting the prophylactic use of intrawound vancomycin powder in spinal fusion surgery and mounting evidence in the arthroplasty literature suggesting that it can reduce surgical site infections. As a result, a number of shoulder arthroplasty surgeons have adopted this practice, despite a paucity of evidence and the presence of a pathogen that is, for the most part, unique to this area of the body—Propionibacterium acnes. The purpose of this study was to evaluate the efficacy of vancomycin against planktonic P. acnes in vitro, using time-dependent concentrations one would expect in vivo after intra-articular application.

Full article available: https://doi.org/10.1016/j.jses.2017.08.001

The Journal of Shoulder and Elbow Surgery

Volume 1, Issue 3, October 2017, Pages 125-128
open access